Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

BACKGROUND: Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops. The rapid removal of degenerated myelin by phagocytosis is advantageous for repair since molecules in myelin impede regenerati...

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Detalles Bibliográficos
Autores principales: Gitik, Miri, Liraz-Zaltsman, Sigal, Oldenborg, Per-Arne, Reichert, Fanny, Rotshenker, Shlomo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068094/
https://www.ncbi.nlm.nih.gov/pubmed/21401967
http://dx.doi.org/10.1186/1742-2094-8-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068094/
https://www.ncbi.nlm.nih.gov/pubmed/21401967
http://dx.doi.org/10.1186/1742-2094-8-24

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