Efficient and Cost Effective Population Resequencing by Pooling and In-Solution Hybridization

High-throughput sequencing of targeted genomic loci in large populations is an effective approach for evaluating the contribution of rare variants to disease risk. We evaluated the feasibility of using in-solution hybridization-based target capture on pooled DNA samples to enable cost-efficient popu...

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Detalles Bibliográficos
Autores principales: Bansal, Vikas, Tewhey, Ryan, LeProust, Emily M., Schork, Nicholas J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068187/
https://www.ncbi.nlm.nih.gov/pubmed/21479135
http://dx.doi.org/10.1371/journal.pone.0018353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068187/
https://www.ncbi.nlm.nih.gov/pubmed/21479135
http://dx.doi.org/10.1371/journal.pone.0018353

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