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Efficient and Cost Effective Population Resequencing by Pooling and In-Solution Hybridization
High-throughput sequencing of targeted genomic loci in large populations is an effective approach for evaluating the contribution of rare variants to disease risk. We evaluated the feasibility of using in-solution hybridization-based target capture on pooled DNA samples to enable cost-efficient popu...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068187/ https://www.ncbi.nlm.nih.gov/pubmed/21479135 http://dx.doi.org/10.1371/journal.pone.0018353 |