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Pre-synaptic HCN1 channels regulate excitatory neurotransmission at select cortical synapses by altering Ca(V)3.2 Ca(2+) channel activity

The Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channels are subthreshold, voltage-gated ion channels that are highly expressed in hippocampal and cortical pyramidal cell dendrites, where they play an important role in regulating synaptic potential integration and plasticity. Here, we...

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Detalles Bibliográficos
Autores principales: Huang, Zhuo, Lujan, Rafael, Kadurin, Ivan, Uebele, Victor N., Renger, John J., Dolphin, Annette C., Shah, Mala M.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068302/
https://www.ncbi.nlm.nih.gov/pubmed/21358644
http://dx.doi.org/10.1038/nn.2757