Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities

BACKGROUND: Aurora-A is a bona-fide oncogene whose expression is associated with genomic instability and malignant transformation. In several types of cancer, gene amplification and/or increased protein levels of Aurora-A are a common feature. RESULTS: In this report, we describe that inhibition of...

Descripción completa

Detalles Bibliográficos
Autores principales: Jantscher, Florian, Pirker, Christine, Mayer, Christoph-Erik, Berger, Walter, Sutterluety, Hedwig
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068985/
https://www.ncbi.nlm.nih.gov/pubmed/21410931
http://dx.doi.org/10.1186/1476-4598-10-28

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068985/
https://www.ncbi.nlm.nih.gov/pubmed/21410931
http://dx.doi.org/10.1186/1476-4598-10-28

Ejemplares similares