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Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities
BACKGROUND: Aurora-A is a bona-fide oncogene whose expression is associated with genomic instability and malignant transformation. In several types of cancer, gene amplification and/or increased protein levels of Aurora-A are a common feature. RESULTS: In this report, we describe that inhibition of...
Autores principales: | Jantscher, Florian, Pirker, Christine, Mayer, Christoph-Erik, Berger, Walter, Sutterluety, Hedwig |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068985/ https://www.ncbi.nlm.nih.gov/pubmed/21410931 http://dx.doi.org/10.1186/1476-4598-10-28 |
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