Botulinum Neurotoxin D Uses Synaptic Vesicle Protein SV2 and Gangliosides as Receptors

Botulinum neurotoxins (BoNTs) include seven bacterial toxins (BoNT/A-G) that target presynaptic terminals and act as proteases cleaving proteins required for synaptic vesicle exocytosis. Here we identified synaptic vesicle protein SV2 as the protein receptor for BoNT/D. BoNT/D enters cultured hippoc...

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Detalles Bibliográficos
Autores principales: Peng, Lisheng, Tepp, William H., Johnson, Eric A., Dong, Min
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068998/
https://www.ncbi.nlm.nih.gov/pubmed/21483489
http://dx.doi.org/10.1371/journal.ppat.1002008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068998/
https://www.ncbi.nlm.nih.gov/pubmed/21483489
http://dx.doi.org/10.1371/journal.ppat.1002008

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