Novel Escape Mutants Suggest an Extensive TRIM5α Binding Site Spanning the Entire Outer Surface of the Murine Leukemia Virus Capsid Protein

After entry into target cells, retroviruses encounter the host restriction factors such as Fv1 and TRIM5α. While it is clear that these factors target retrovirus capsid proteins (CA), recognition remains poorly defined in the absence of structural information. To better understand the binding intera...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohkura, Sadayuki, Goldstone, David C., Yap, Melvyn W., Holden-Dye, Kate, Taylor, Ian A., Stoye, Jonathan P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068999/
https://www.ncbi.nlm.nih.gov/pubmed/21483490
http://dx.doi.org/10.1371/journal.ppat.1002011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068999/
https://www.ncbi.nlm.nih.gov/pubmed/21483490
http://dx.doi.org/10.1371/journal.ppat.1002011

Ejemplares similares