Structural Asymmetry of Phosphodiesterase-9, Potential Protonation of a Glutamic Acid, and Role of the Invariant Glutamine

PDE9 inhibitors show potential for treatment of diseases such as diabetes. To help with discovery of PDE9 inhibitors, we performed mutagenesis, kinetic, crystallographic, and molecular dynamics analyses on the active site residues of Gln453 and its stabilizing partner Glu406. The crystal structures...

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Detalles Bibliográficos
Autores principales: Hou, Jing, Xu, Jie, Liu, Ming, Zhao, Ruizhi, Luo, Hai-Bin, Ke, Hengming
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069055/
https://www.ncbi.nlm.nih.gov/pubmed/21483814
http://dx.doi.org/10.1371/journal.pone.0018092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069055/
https://www.ncbi.nlm.nih.gov/pubmed/21483814
http://dx.doi.org/10.1371/journal.pone.0018092

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