Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1

Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness losses due to the accumulation of deleterious mutations and thus could influen...

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Detalles Bibliográficos
Autores principales: Martínez, Javier P., Bocharov, Gennady, Ignatovich, Anna, Reiter, Jochen, Dittmar, Matthias T., Wain-Hobson, Simon, Meyerhans, Andreas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069090/
https://www.ncbi.nlm.nih.gov/pubmed/21483787
http://dx.doi.org/10.1371/journal.pone.0018375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069090/
https://www.ncbi.nlm.nih.gov/pubmed/21483787
http://dx.doi.org/10.1371/journal.pone.0018375

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