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Fitness Ranking of Individual Mutants Drives Patterns of Epistatic Interactions in HIV-1
Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness losses due to the accumulation of deleterious mutations and thus could influen...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069090/ https://www.ncbi.nlm.nih.gov/pubmed/21483787 http://dx.doi.org/10.1371/journal.pone.0018375 |