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Ligand independent activation of c-Met by fibronectin and α(5)β(1)-integrin regulates ovarian cancer invasion and metastasis

The role of the fibronectin receptor, α(5)β(1)-integrin, as an adhesion receptor and in angiogenesis, is well established. However, its role in cancer cell invasion and metastasis is less clear. We describe a novel mechanism by which fibronectin regulates ovarian cancer cell signaling and promotes m...

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Detalles Bibliográficos
Autores principales: Mitra, AK, Sawada, K, Tiwari, P, Mui, K, Gwin, K, Lengyel, E
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069218/
https://www.ncbi.nlm.nih.gov/pubmed/21119598
http://dx.doi.org/10.1038/onc.2010.532