Electrostatic Clustering and Free Energy Calculations Provide a Foundation for Protein Design and Optimization

Electrostatic interactions are ubiquitous in proteins and dictate stability and function. In this review, we discuss several methods for the analysis of electrostatics in protein–protein interactions. We discuss alanine-scanning mutagenesis, Poisson–Boltzmann electrostatics, free energy calculations...

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Detalles Bibliográficos
Autores principales: Gorham, Ronald D., Kieslich, Chris A., Morikis, Dimitrios
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069318/
https://www.ncbi.nlm.nih.gov/pubmed/21140293
http://dx.doi.org/10.1007/s10439-010-0226-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069318/
https://www.ncbi.nlm.nih.gov/pubmed/21140293
http://dx.doi.org/10.1007/s10439-010-0226-9

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