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Electrostatic Clustering and Free Energy Calculations Provide a Foundation for Protein Design and Optimization
Electrostatic interactions are ubiquitous in proteins and dictate stability and function. In this review, we discuss several methods for the analysis of electrostatics in protein–protein interactions. We discuss alanine-scanning mutagenesis, Poisson–Boltzmann electrostatics, free energy calculations...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069318/ https://www.ncbi.nlm.nih.gov/pubmed/21140293 http://dx.doi.org/10.1007/s10439-010-0226-9 |