PERK Activation at Low Glucose Concentration Is Mediated by SERCA Pump Inhibition and Confers Preemptive Cytoprotection to Pancreatic β-Cells

Protein kinase R-like ER kinase (PERK) is activated at physiologically low glucose concentrations in pancreatic β-cells. However, the molecular mechanisms by which PERK is activated under these conditions and its role in β-cell function are poorly understood. In this report, we investigated, in disp...

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Detalles Bibliográficos
Autores principales: Moore, Claire E., Omikorede, Omotola, Gomez, Edith, Willars, Gary B., Herbert, Terence P.
Formato: Texto
Lenguaje:English
Publicado: Endocrine Society 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070211/
https://www.ncbi.nlm.nih.gov/pubmed/21193559
http://dx.doi.org/10.1210/me.2010-0309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070211/
https://www.ncbi.nlm.nih.gov/pubmed/21193559
http://dx.doi.org/10.1210/me.2010-0309

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