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Physical disruption of skin during poxvirus immunization is critical for the generation of highly protective T cell-mediated immunity

Variola major infection (Smallpox) claimed hundreds of millions lives before it was eradicated by a simple vaccination strategy: epicutaneous application of the related orthopoxvirus Vaccinia virus (VACV) to superficially injured skin (skin scarification, s.s.)1. However, the remarkable success of t...

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Detalles Bibliográficos
Autores principales: Liu, Luzheng, Zhong, Qiong, Tian, Tian, Dubin, Krista, Athale, Shruti K., Kupper, Thomas S.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070948/
https://www.ncbi.nlm.nih.gov/pubmed/20081864
http://dx.doi.org/10.1038/nm.2078