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Physical disruption of skin during poxvirus immunization is critical for the generation of highly protective T cell-mediated immunity
Variola major infection (Smallpox) claimed hundreds of millions lives before it was eradicated by a simple vaccination strategy: epicutaneous application of the related orthopoxvirus Vaccinia virus (VACV) to superficially injured skin (skin scarification, s.s.)1. However, the remarkable success of t...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070948/ https://www.ncbi.nlm.nih.gov/pubmed/20081864 http://dx.doi.org/10.1038/nm.2078 |