High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

BACKGROUND: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form an active protein kinase complex with Leishman...

Descripción completa

Detalles Bibliográficos
Autores principales: Walker, Roderick G., Thomson, Graeme, Malone, Kirk, Nowicki, Matthew W., Brown, Elaine, Blake, David G., Turner, Nicholas J., Walkinshaw, Malcolm D., Grant, Karen M., Mottram, Jeremy C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071374/
https://www.ncbi.nlm.nih.gov/pubmed/21483720
http://dx.doi.org/10.1371/journal.pntd.0001033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071374/
https://www.ncbi.nlm.nih.gov/pubmed/21483720
http://dx.doi.org/10.1371/journal.pntd.0001033

Ejemplares similares