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Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption
We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci ach...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071630/ https://www.ncbi.nlm.nih.gov/pubmed/21490707 http://dx.doi.org/10.1371/journal.pgen.1002033 |
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| author | Cornelis, Marilyn C. Monda, Keri L. Yu, Kai Paynter, Nina Azzato, Elizabeth M. Bennett, Siiri N. Berndt, Sonja I. Boerwinkle, Eric Chanock, Stephen Chatterjee, Nilanjan Couper, David Curhan, Gary Heiss, Gerardo Hu, Frank B. Hunter, David J. Jacobs, Kevin Jensen, Majken K. Kraft, Peter Landi, Maria Teresa Nettleton, Jennifer A. Purdue, Mark P. Rajaraman, Preetha Rimm, Eric B. Rose, Lynda M. Rothman, Nathaniel Silverman, Debra Stolzenberg-Solomon, Rachael Subar, Amy Yeager, Meredith Chasman, Daniel I. van Dam, Rob M. Caporaso, Neil E. |
| author_facet | Cornelis, Marilyn C. Monda, Keri L. Yu, Kai Paynter, Nina Azzato, Elizabeth M. Bennett, Siiri N. Berndt, Sonja I. Boerwinkle, Eric Chanock, Stephen Chatterjee, Nilanjan Couper, David Curhan, Gary Heiss, Gerardo Hu, Frank B. Hunter, David J. Jacobs, Kevin Jensen, Majken K. Kraft, Peter Landi, Maria Teresa Nettleton, Jennifer A. Purdue, Mark P. Rajaraman, Preetha Rimm, Eric B. Rose, Lynda M. Rothman, Nathaniel Silverman, Debra Stolzenberg-Solomon, Rachael Subar, Amy Yeager, Meredith Chasman, Daniel I. van Dam, Rob M. Caporaso, Neil E. |
| author_sort | Cornelis, Marilyn C. |
| collection | PubMed |
| description | We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4×10(−19)), near AHR, and 15q24 (P = 5.2×10(−14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2. |
| format | Text |
| id | pubmed-3071630 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-30716302011-04-13 Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption Cornelis, Marilyn C. Monda, Keri L. Yu, Kai Paynter, Nina Azzato, Elizabeth M. Bennett, Siiri N. Berndt, Sonja I. Boerwinkle, Eric Chanock, Stephen Chatterjee, Nilanjan Couper, David Curhan, Gary Heiss, Gerardo Hu, Frank B. Hunter, David J. Jacobs, Kevin Jensen, Majken K. Kraft, Peter Landi, Maria Teresa Nettleton, Jennifer A. Purdue, Mark P. Rajaraman, Preetha Rimm, Eric B. Rose, Lynda M. Rothman, Nathaniel Silverman, Debra Stolzenberg-Solomon, Rachael Subar, Amy Yeager, Meredith Chasman, Daniel I. van Dam, Rob M. Caporaso, Neil E. PLoS Genet Research Article We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4×10(−19)), near AHR, and 15q24 (P = 5.2×10(−14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2. Public Library of Science 2011-04-07 /pmc/articles/PMC3071630/ /pubmed/21490707 http://dx.doi.org/10.1371/journal.pgen.1002033 Text en This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
| spellingShingle | Research Article Cornelis, Marilyn C. Monda, Keri L. Yu, Kai Paynter, Nina Azzato, Elizabeth M. Bennett, Siiri N. Berndt, Sonja I. Boerwinkle, Eric Chanock, Stephen Chatterjee, Nilanjan Couper, David Curhan, Gary Heiss, Gerardo Hu, Frank B. Hunter, David J. Jacobs, Kevin Jensen, Majken K. Kraft, Peter Landi, Maria Teresa Nettleton, Jennifer A. Purdue, Mark P. Rajaraman, Preetha Rimm, Eric B. Rose, Lynda M. Rothman, Nathaniel Silverman, Debra Stolzenberg-Solomon, Rachael Subar, Amy Yeager, Meredith Chasman, Daniel I. van Dam, Rob M. Caporaso, Neil E. Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption |
| title | Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption |
| title_full | Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption |
| title_fullStr | Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption |
| title_full_unstemmed | Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption |
| title_short | Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption |
| title_sort | genome-wide meta-analysis identifies regions on 7p21 (ahr) and 15q24 (cyp1a2) as determinants of habitual caffeine consumption |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071630/ https://www.ncbi.nlm.nih.gov/pubmed/21490707 http://dx.doi.org/10.1371/journal.pgen.1002033 |
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