Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

Parkin, an E3 ubiquitin ligase implicated in Parkinson's disease, promotes degradation of dysfunctional mitochondria by autophagy. Using proteomic and cellular approaches, we show that upon translocation to mitochondria, Parkin activates the ubiquitin–proteasome system (UPS) for widespread degr...

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Detalles Bibliográficos
Autores principales: Chan, Nickie C., Salazar, Anna M., Pham, Anh H., Sweredoski, Michael J., Kolawa, Natalie J., Graham, Robert L.J., Hess, Sonja, Chan, David C.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071670/
https://www.ncbi.nlm.nih.gov/pubmed/21296869
http://dx.doi.org/10.1093/hmg/ddr048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071670/
https://www.ncbi.nlm.nih.gov/pubmed/21296869
http://dx.doi.org/10.1093/hmg/ddr048

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