Optimizing the Design of Oligonucleotides for Homology Directed Gene Targeting

BACKGROUND: Gene targeting depends on the ability of cells to use homologous recombination to integrate exogenous DNA into their own genome. A robust mechanistic model of homologous recombination is necessary to fully exploit gene targeting for therapeutic benefit. METHODOLOGY/PRINCIPAL FINDINGS: In...

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Detalles Bibliográficos
Autores principales: Miné-Hattab, Judith, Fleury, Geneviève, Prevost, Chantal, Dutreix, Marie, Viovy, Jean-Louis
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071677/
https://www.ncbi.nlm.nih.gov/pubmed/21483664
http://dx.doi.org/10.1371/journal.pone.0014795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071677/
https://www.ncbi.nlm.nih.gov/pubmed/21483664
http://dx.doi.org/10.1371/journal.pone.0014795

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