Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical features that are largely indistinguishab...

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Detalles Bibliográficos
Autores principales: Ramonet, David, Daher, João Paulo L., Lin, Brian M., Stafa, Klodjan, Kim, Jaekwang, Banerjee, Rebecca, Westerlund, Marie, Pletnikova, Olga, Glauser, Liliane, Yang, Lichuan, Liu, Ying, Swing, Deborah A., Beal, M. Flint, Troncoso, Juan C., McCaffery, J. Michael, Jenkins, Nancy A., Copeland, Neal G., Galter, Dagmar, Thomas, Bobby, Lee, Michael K., Dawson, Ted M., Dawson, Valina L., Moore, Darren J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071839/
https://www.ncbi.nlm.nih.gov/pubmed/21494637
http://dx.doi.org/10.1371/journal.pone.0018568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071839/
https://www.ncbi.nlm.nih.gov/pubmed/21494637
http://dx.doi.org/10.1371/journal.pone.0018568

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