shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa

In vertebrate rods, dark and light conditions produce changes in guanosine 3′,5′-cyclic monophosphate (cGMP) and calcium (Ca(2+)) levels, which are regulated by the opposing function of several proteins. During the recovery of a bright flash, guanylate cyclase (GUCY) helps raise cGMP to levels that...

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Detalles Bibliográficos
Autores principales: Tosi, Joaquin, Davis, Richard J, Wang, Nan-Kai, Naumann, Matthew, Lin, Chyuan-Sheng, Tsang, Stephen H
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071858/
https://www.ncbi.nlm.nih.gov/pubmed/20950332
http://dx.doi.org/10.1111/j.1582-4934.2010.01201.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071858/
https://www.ncbi.nlm.nih.gov/pubmed/20950332
http://dx.doi.org/10.1111/j.1582-4934.2010.01201.x

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