Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

SUMMARY: Background: Activated factor XIII (FXIIIa), a transglutaminase, introduces fibrin–fibrin and fibrin–inhibitor cross-links, resulting in more mechanically stable clots. The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively. Methods:We use...

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Detalles Bibliográficos
Autores principales: Mutch, N J, Koikkalainen, J S, Fraser, S R, Duthie, K M, Griffin, M, Mitchell, J, Watson, H G, Booth, N A
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Fibrinolysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071935/
https://www.ncbi.nlm.nih.gov/pubmed/20586921
http://dx.doi.org/10.1111/j.1538-7836.2010.03963.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071935/
https://www.ncbi.nlm.nih.gov/pubmed/20586921
http://dx.doi.org/10.1111/j.1538-7836.2010.03963.x

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