Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease

Huntington’s disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating...

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Detalles Bibliográficos
Autores principales: Oakeshott, Stephen, Balci, Fuat, Filippov, Igor, Murphy, Carol, Port, Russell, Connor, David, Paintdakhi, Ahmad, LeSauter, Joseph, Menalled, Liliana, Ramboz, Sylvie, Kwak, Seung, Howland, David, Silver, Rae, Brunner, Dani
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Huntington Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072044/
https://www.ncbi.nlm.nih.gov/pubmed/21479110
http://dx.doi.org/10.1371/currents.RRN1225
Descripción
Sumario:Huntington’s disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating with symptom severity in patients. Here, we studied the behavior of the BAC HD mouse model using an 24/7 automated system; the results indicate significant lengthening of the circadian period in the mutant mice. These results reinforce previous findings in HD models and symptomatic HD patients, indicating that circadian dysfunction is a core feature of HD.

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