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Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease
Huntington’s disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072044/ https://www.ncbi.nlm.nih.gov/pubmed/21479110 http://dx.doi.org/10.1371/currents.RRN1225 |
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author | Oakeshott, Stephen Balci, Fuat Filippov, Igor Murphy, Carol Port, Russell Connor, David Paintdakhi, Ahmad LeSauter, Joseph Menalled, Liliana Ramboz, Sylvie Kwak, Seung Howland, David Silver, Rae Brunner, Dani |
author_facet | Oakeshott, Stephen Balci, Fuat Filippov, Igor Murphy, Carol Port, Russell Connor, David Paintdakhi, Ahmad LeSauter, Joseph Menalled, Liliana Ramboz, Sylvie Kwak, Seung Howland, David Silver, Rae Brunner, Dani |
author_sort | Oakeshott, Stephen |
collection | PubMed |
description | Huntington’s disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating with symptom severity in patients. Here, we studied the behavior of the BAC HD mouse model using an 24/7 automated system; the results indicate significant lengthening of the circadian period in the mutant mice. These results reinforce previous findings in HD models and symptomatic HD patients, indicating that circadian dysfunction is a core feature of HD. |
format | Text |
id | pubmed-3072044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30720442011-04-07 Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease Oakeshott, Stephen Balci, Fuat Filippov, Igor Murphy, Carol Port, Russell Connor, David Paintdakhi, Ahmad LeSauter, Joseph Menalled, Liliana Ramboz, Sylvie Kwak, Seung Howland, David Silver, Rae Brunner, Dani PLoS Curr Huntington Disease Huntington’s disease (HD) is a progressive neurodegenerative disease marked by psychiatric and motor problems. Recently, these findings have been extended to deficits in sleep and circadian function that can be observed in HD patients and in HD mouse models, with abnormal sleep patterns correlating with symptom severity in patients. Here, we studied the behavior of the BAC HD mouse model using an 24/7 automated system; the results indicate significant lengthening of the circadian period in the mutant mice. These results reinforce previous findings in HD models and symptomatic HD patients, indicating that circadian dysfunction is a core feature of HD. Public Library of Science 2011-04-05 /pmc/articles/PMC3072044/ /pubmed/21479110 http://dx.doi.org/10.1371/currents.RRN1225 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Huntington Disease Oakeshott, Stephen Balci, Fuat Filippov, Igor Murphy, Carol Port, Russell Connor, David Paintdakhi, Ahmad LeSauter, Joseph Menalled, Liliana Ramboz, Sylvie Kwak, Seung Howland, David Silver, Rae Brunner, Dani Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease |
title | Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease |
title_full | Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease |
title_fullStr | Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease |
title_full_unstemmed | Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease |
title_short | Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington’s Disease |
title_sort | circadian abnormalities in motor activity in a bac transgenic mouse model of huntington’s disease |
topic | Huntington Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072044/ https://www.ncbi.nlm.nih.gov/pubmed/21479110 http://dx.doi.org/10.1371/currents.RRN1225 |
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