How mutations in tRNA distant from the anticodon affect the fidelity of decoding

The ribosome converts genetic information into protein by selecting aminoacyl-tRNAs whose anticodons base pair to an mRNA codon. Mutations in the tRNA body can perturb this process and affect fidelity. The Hirsh suppressor is a well-studied tRNA(Trp) harboring a G24A mutation that allows readthrough...

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Detalles Bibliográficos
Autores principales: Schmeing, T. Martin, Voorhees, Rebecca M., Kelley, Ann C., Ramakrishnan, V.
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072312/
https://www.ncbi.nlm.nih.gov/pubmed/21378964
http://dx.doi.org/10.1038/nsmb.2003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072312/
https://www.ncbi.nlm.nih.gov/pubmed/21378964
http://dx.doi.org/10.1038/nsmb.2003

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