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How mutations in tRNA distant from the anticodon affect the fidelity of decoding
The ribosome converts genetic information into protein by selecting aminoacyl-tRNAs whose anticodons base pair to an mRNA codon. Mutations in the tRNA body can perturb this process and affect fidelity. The Hirsh suppressor is a well-studied tRNA(Trp) harboring a G24A mutation that allows readthrough...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072312/ https://www.ncbi.nlm.nih.gov/pubmed/21378964 http://dx.doi.org/10.1038/nsmb.2003 |