SUMO-Interacting Motifs of Human TRIM5α are Important for Antiviral Activity

Human TRIM5α potently restricts particular strains of murine leukemia viruses (the so-called N-tropic strains) but not others (the B- or NB-tropic strains) during early stages of infection. We show that overexpression of SUMO-1 in human 293T cells, but not in mouse MDTF cells, profoundly blocks N-ML...

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Detalles Bibliográficos
Autores principales: Arriagada, Gloria, Muntean, Lucia N., Goff, Stephen P.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072370/
https://www.ncbi.nlm.nih.gov/pubmed/21490953
http://dx.doi.org/10.1371/journal.ppat.1002019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072370/
https://www.ncbi.nlm.nih.gov/pubmed/21490953
http://dx.doi.org/10.1371/journal.ppat.1002019

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