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PDK1-Foxo1 in Agouti-Related Peptide Neurons Regulates Energy Homeostasis by Modulating Food Intake and Energy Expenditure

Insulin and leptin intracellular signaling pathways converge and act synergistically on the hypothalamic phosphatidylinositol-3-OH kinase/3-phosphoinositide-dependent protein kinase 1 (PDK1). However, little is known about whether PDK1 in agouti-related peptide (AGRP) neurons contributes to energy h...

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Detalles Bibliográficos
Autores principales: Cao, Yongheng, Nakata, Masanori, Okamoto, Shiki, Takano, Eisuke, Yada, Toshihiko, Minokoshi, Yasuhiko, Hirata, Yukio, Nakajima, Kazunori, Iskandar, Kristy, Hayashi, Yoshitake, Ogawa, Wataru, Barsh, Gregory S., Hosoda, Hiroshi, Kangawa, Kenji, Itoh, Hiroshi, Noda, Tetsuo, Kasuga, Masato, Nakae, Jun
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072380/
https://www.ncbi.nlm.nih.gov/pubmed/21694754
http://dx.doi.org/10.1371/journal.pone.0018324