Capsid-expressing DNA in AAV vectors and its elimination by use of an oversize capsid gene for vector production

Adeno-associated virus vectors have been shown to mediate persistent transduction in animal models of gene therapy. However, clinical trials with AAV vectors have shown that an immune response to AAV capsid protein can result in clearance of transduced cells. One source of capsid antigen is from the...

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Detalles Bibliográficos
Autores principales: Halbert, Christine L., Metzger, Michael J., Lam, Siu-Ling, Miller, A. Dusty
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072450/
https://www.ncbi.nlm.nih.gov/pubmed/21160534
http://dx.doi.org/10.1038/gt.2010.167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072450/
https://www.ncbi.nlm.nih.gov/pubmed/21160534
http://dx.doi.org/10.1038/gt.2010.167

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