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GNL3L Depletion Destabilizes MDM2 and Induces p53-Dependent G2/M Arrest
Guanine nucleotide binding protein-like 3-like (GNL3L) is a nucleolar protein and the vertebrate paralogue of nucleostemin (NS). We previously reported that nucleoplasmic mobilization of NS stabilizes MDM2 (mouse double minute 2). Here, we investigated the role of GNL3L as a novel MDM2 regulator. We...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072457/ https://www.ncbi.nlm.nih.gov/pubmed/21132010 http://dx.doi.org/10.1038/onc.2010.550 |