Activation of protein kinase R is required for induction of stress granules by respiratory syncytial virus but dispensable for viral replication

We performed experiments to determine the effect of PKR activation on respiratory syncytial virus (RSV) replication. We first determined that RSV infection activates PKR which induces the phosphorylation of eIF2α, resulting in the formation of host stress granules. We used RNA interference to decrea...

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Detalles Bibliográficos
Autores principales: Lindquist, Michael E., Mainou, Bernardo A., Dermody, Terence S., Crowe, James E.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Inc. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072468/
https://www.ncbi.nlm.nih.gov/pubmed/21377708
http://dx.doi.org/10.1016/j.virol.2011.02.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072468/
https://www.ncbi.nlm.nih.gov/pubmed/21377708
http://dx.doi.org/10.1016/j.virol.2011.02.009

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