High levels of the adhesion molecule CD44 on leukemic cells generate acute myeloid leukemia relapse after withdrawal of the initial transforming event

Multiple genetic hits are detected in patients with acute myeloid leukemia (AML). To investigate this further, we developed a tetracycline-inducible mouse model of AML, in which the initial transforming event, overexpression of HOXA10, can be eliminated. Continuous overexpression of HOXA10 is requir...

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Detalles Bibliográficos
Autores principales: Quéré, R, Andradottir, S, Brun, A C M, Zubarev, R A, Karlsson, G, Olsson, K, Magnusson, M, Cammenga, J, Karlsson, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072510/
https://www.ncbi.nlm.nih.gov/pubmed/21116281
http://dx.doi.org/10.1038/leu.2010.281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072510/
https://www.ncbi.nlm.nih.gov/pubmed/21116281
http://dx.doi.org/10.1038/leu.2010.281

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