Mitogenic Sonic hedgehog signaling drives E2F1-dependent lipogenesis in progenitor cells and Medulloblastoma

Deregulation of the Rb/E2F tumor suppressor complex and aberrantion of Sonic hedgehog (Shh) signaling are documented across the spectrum of human malignancies. Exaggerated de novo lipid synthesis is also found in certain highly proliferative, aggressive tumors. Here, we show that in Shh-driven medul...

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Detalles Bibliográficos
Autores principales: Bhatia, Bobby, Hsieh, Michael, Kenney, Anna Marie, Nahlé, Zaher
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072890/
https://www.ncbi.nlm.nih.gov/pubmed/20890301
http://dx.doi.org/10.1038/onc.2010.454

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072890/
https://www.ncbi.nlm.nih.gov/pubmed/20890301
http://dx.doi.org/10.1038/onc.2010.454

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