Dose Effects of Oxaliplatin on Persistent and Transient Na(+) Conductances and the Development of Neurotoxicity

BACKGROUND: Oxaliplatin, a platinum-based chemotherapy utilised in the treatment of colorectal cancer, produces two forms of neurotoxicity- acute sensorimotor neuropathic symptoms and a dose-limiting chronic sensory neuropathy. Given that a Na(+) channelopathy has been proposed as the mechanism unde...

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Detalles Bibliográficos
Autores principales: Park, Susanna B., Lin, Cindy S-Y., Krishnan, Arun V., Goldstein, David, Friedlander, Michael L., Kiernan, Matthew C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072981/
https://www.ncbi.nlm.nih.gov/pubmed/21494615
http://dx.doi.org/10.1371/journal.pone.0018469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072981/
https://www.ncbi.nlm.nih.gov/pubmed/21494615
http://dx.doi.org/10.1371/journal.pone.0018469

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