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Dose Effects of Oxaliplatin on Persistent and Transient Na(+) Conductances and the Development of Neurotoxicity
BACKGROUND: Oxaliplatin, a platinum-based chemotherapy utilised in the treatment of colorectal cancer, produces two forms of neurotoxicity- acute sensorimotor neuropathic symptoms and a dose-limiting chronic sensory neuropathy. Given that a Na(+) channelopathy has been proposed as the mechanism unde...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072981/ https://www.ncbi.nlm.nih.gov/pubmed/21494615 http://dx.doi.org/10.1371/journal.pone.0018469 |