Targeting BRAF(V600E) with PLX4720 Displays Potent Antimigratory and Anti-invasive Activity in Preclinical Models of Human Thyroid Cancer

PURPOSE. B-Raf(V600E) may play a role in the progression from papillary thyroid cancer to anaplastic thyroid cancer (ATC). We tested the effects of a highly selective B-Raf(V600E) inhibitor, PLX4720, on proliferation, migration, and invasion both in human thyroid cancer cell lines (8505c(B-RafV600E)...

Descripción completa

Detalles Bibliográficos
Autores principales: Nucera, Carmelo, Nehs, Matthew A., Nagarkatti, Sushruta S., Sadow, Peter M., Mekel, Michal, Fischer, Andrew H., Lin, Paul S., Bollag, Gideon E., Lawler, Jack, Hodin, Richard A., Parangi, Sareh
Formato: Texto
Lenguaje:English
Publicado: AlphaMed Press 2011
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073446/
https://www.ncbi.nlm.nih.gov/pubmed/21355020
http://dx.doi.org/10.1634/theoncologist.2010-0317

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073446/
https://www.ncbi.nlm.nih.gov/pubmed/21355020
http://dx.doi.org/10.1634/theoncologist.2010-0317

Ejemplares similares