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Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status

BACKGROUND: In the bone marrow, hematopietic and mesenchymal stem cells form a unique niche in which the oxygen tension is low. Hypoxia may have a role in maintaining stem cell fate, self renewal and multipotency. However, whereas most studies addressed the effect of transient in vitro exposure of M...

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Detalles Bibliográficos
Autores principales:	Basciano, Leticia, Nemos, Christophe, Foliguet, Bernard, de Isla, Natalia, de Carvalho, Marcelo, Tran, Nguyen, Dalloul, Ali
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073900/ https://www.ncbi.nlm.nih.gov/pubmed/21450070 http://dx.doi.org/10.1186/1471-2121-12-12

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