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A Model of a MAPK•Substrate Complex in an Active Conformation: A Computational and Experimental Approach
The mechanisms by which MAP kinases recognize and phosphorylate substrates are not completely understood. Efforts to understand the mechanisms have been compromised by the lack of MAPK-substrate structures. While MAPK-substrate docking is well established as a viable mechanism for bringing MAPKs and...
Autores principales: | Lee, Sunbae, Warthaka, Mangalika, Yan, Chunli, Kaoud, Tamer S., Piserchio, Andrea, Ghose, Ranajeet, Ren, Pengyu, Dalby, Kevin N. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073974/ https://www.ncbi.nlm.nih.gov/pubmed/21494553 http://dx.doi.org/10.1371/journal.pone.0018594 |
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