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BR-squared: a practical solution to the winner’s curse in genome-wide scans
The detrimental effects of the winner’s curse, including overestimation of the genetic effects of associated variants and underestimation of sufficient sample sizes for replication studies are well-recognized in genome-wide association studies (GWAS). These effects can be expected to worsen as the f...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074069/ https://www.ncbi.nlm.nih.gov/pubmed/21246217 http://dx.doi.org/10.1007/s00439-011-0948-2 |