BR-squared: a practical solution to the winner’s curse in genome-wide scans

The detrimental effects of the winner’s curse, including overestimation of the genetic effects of associated variants and underestimation of sufficient sample sizes for replication studies are well-recognized in genome-wide association studies (GWAS). These effects can be expected to worsen as the f...

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Detalles Bibliográficos
Autores principales: Sun, Lei, Dimitromanolakis, Apostolos, Faye, Laura L., Paterson, Andrew D., Waggott, Daryl, Bull, Shelley B.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074069/
https://www.ncbi.nlm.nih.gov/pubmed/21246217
http://dx.doi.org/10.1007/s00439-011-0948-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074069/
https://www.ncbi.nlm.nih.gov/pubmed/21246217
http://dx.doi.org/10.1007/s00439-011-0948-2

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