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Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing
MicroRNAs (miRNAs) are prevalent regulatory RNAs that mediate gene silencing and play key roles in diverse cellular processes. While synthetic RNA-based regulatory systems that integrate regulatory and sensing functions have been demonstrated, the lack of detail on miRNA structure–function relations...
Autores principales: | Beisel, Chase L., Chen, Yvonne Y., Culler, Stephanie J., Hoff, Kevin G., Smolke, Christina D. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074164/ https://www.ncbi.nlm.nih.gov/pubmed/21149259 http://dx.doi.org/10.1093/nar/gkq954 |
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