Cargando…

Structure and Function of an Irreversible Agonist-β(2) Adrenoceptor complex

G protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that modulate biological function by initiating cellular signaling in response to chemically diverse agonists. Despite recent progress in the structural biology of GPCRs1, the molecular basis for agonist binding and allost...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rosenbaum, Daniel M., Zhang, Cheng, Lyons, Joseph, Holl, Ralph, Aragao, David, Arlow, Daniel H., Rasmussen, Søren G. F., Choi, Hee-Jung, DeVree, Brian T., Sunahara, Roger K., Chae, Pil Seok, Gellman, Samuel H., Dror, Ron O., Shaw, David E., Weis, William I., Caffrey, Martin, Gmeiner, Peter, Kobilka, Brian K.
Formato:	Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074335/ https://www.ncbi.nlm.nih.gov/pubmed/21228876 http://dx.doi.org/10.1038/nature09665

Ejemplares similares

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor
por: Rasmussen, Søren G. F., et al.
Publicado: (2011)

Ligand-regulated oligomerization of β(2)-adrenoceptors in a model lipid bilayer
por: Fung, Juan José, et al.
Publicado: (2009)

Crystal Structure of the β(2)Adrenergic Receptor-Gs protein complex
por: Rasmussen, Søren G.F., et al.
Publicado: (2011)

Structure and Dynamics of the M(3) Muscarinic Acetylcholine Receptor
por: Kruse, Andrew C., et al.
Publicado: (2012)

Adrenaline-activated structure of the β(2)-adrenoceptor stabilized by an engineered nanobody
por: Ring, Aaron M., et al.
Publicado: (2013)

Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor
por: Cai, Yingying, et al.
Publicado: (2017)

Allosteric coupling from G protein to the agonist binding pocket in GPCRs
por: DeVree, Brian T., et al.
Publicado: (2016)

High-resolution crystal structure of human Protease-Activated Receptor 1 bound to the antagonist vorapaxar
por: Zhang, Cheng, et al.
Publicado: (2012)

Organization of β-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes
por: Shcherbakova, Olga G., et al.
Publicado: (2007)

Pharmacological Characterization of Purified Full-Length Dopamine Transporter from Drosophila melanogaster
por: Pugh, Ciara Frances, et al.
Publicado: (2022)

Constrained catecholamines gain β(2)AR selectivity through allosteric effects on pocket dynamics
por: Xu, Xinyu, et al.
Publicado: (2023)

Author Correction: Constrained catecholamines gain β(2)AR selectivity through allosteric effects on pocket dynamics
por: Xu, Xinyu, et al.
Publicado: (2023)

Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
por: Manglik, Aashish, et al.
Publicado: (2012)

Current and future advances in fluorescence-based visualization of plant cell wall components and cell wall biosynthetic machineries
por: DeVree, Brian T, et al.
Publicado: (2021)

N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor
por: Zou, Yaozhong, et al.
Publicado: (2012)

Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach
por: Chung, Ka Young, et al.
Publicado: (2013)

Applications of molecular replacement to G protein-coupled receptors
por: Kruse, Andrew C., et al.
Publicado: (2013)

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins
por: Chae, Pil Seok, et al.
Publicado: (2010)

The Role of Adrenoceptors in Bronchial Asthma
por: Patel, K. R.
Publicado: (1979)

Structure of the δ-opioid receptor bound to naltrindole
por: Granier, Sébastien, et al.
Publicado: (2012)

Ligand-specific regulation of the extracellular surface of a G protein coupled receptor
por: Bokoch, Michael P., et al.
Publicado: (2010)

Structural insights into binding specificity, efficacy and bias of a β(2)AR partial agonist
por: Masureel, Matthieu, et al.
Publicado: (2018)

The Role of Adrenoceptors in the Retina
por: Ruan, Yue, et al.
Publicado: (2020)

Treatment of Hypertension with Beta-Adrenoceptor Blocking Drugs
por: Bai, Tony R., et al.
Publicado: (1982)

Thermo field dynamics of irreversible processes
por: Watanabe, K, et al.
Publicado: (1998)

Structure‐Based Evolution of G Protein‐Biased μ‐Opioid Receptor Agonists
por: Wang, Haoqing, et al.
Publicado: (2022)

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
por: Liu, Hongtao, et al.
Publicado: (2018)

Extended Irreversible Thermodynamics
por: Jou, David, et al.
Publicado: (2010)

Celiprolol: A Unique Selective Adrenoceptor Modulator
por: Nawarskas, James J., et al.
Publicado: (2017)

Relationships of Adrenoceptor Polymorphisms with Obesity
por: Masuo, Kazuko, et al.
Publicado: (2011)

Adrenal adrenoceptors in heart failure
por: de Lucia, Claudio, et al.
Publicado: (2014)

A Full Pharmacological Analysis of the Three Turkey β-Adrenoceptors and Comparison with the Human β-Adrenoceptors
por: Baker, Jillian G.
Publicado: (2010)

β-Adrenoceptor-mediated Relaxation of Urinary Bladder Muscle in β(2)-Adrenoceptor Knockout Mice
por: Propping, Stefan, et al.
Publicado: (2016)

Extended irreversible thermodynamics
por: Jou, David, et al.
Publicado: (1993)

Extended irreversible thermodynamics
por: Jou, David, et al.
Publicado: (1996)

Extended irreversible thermodynamics
por: Jou, David, et al.
Publicado: (2001)

Thermodynamics of irreversible processes
por: Lavenda, Bernard H.
Publicado: (1993)

Structural insights into μ-opioid receptor activation
por: Huang, Weijiao, et al.
Publicado: (2015)

Characterising the Mechanism of Airway Smooth Muscle β(2) Adrenoceptor Desensitization by Rhinovirus Infected Bronchial Epithelial Cells
por: Van Ly, David, et al.
Publicado: (2013)

Irreversibility in dynamical phases and transitions
por: Seara, Daniel S., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_16p49edc5anisjei1jnbtq1ub7