Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice

We employed the Cre recombinase/loxP system to create a mouse line in which PKA activity can be inhibited in any cell-type that expresses Cre recombinase. The mouse line carries a mutant Prkar1a allele encoding a glycine to aspartate substitution at position 324 in the carboxy-terminal cAMP-binding...

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Detalles Bibliográficos
Autores principales: Willis, Brandon S., Niswender, Colleen M., Su, Thomas, Amieux, Paul S., McKnight, G. Stanley
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075275/
https://www.ncbi.nlm.nih.gov/pubmed/21533282
http://dx.doi.org/10.1371/journal.pone.0018772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075275/
https://www.ncbi.nlm.nih.gov/pubmed/21533282
http://dx.doi.org/10.1371/journal.pone.0018772

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