Cargando…

Cell-Type Specific Expression of a Dominant Negative PKA Mutation in Mice

We employed the Cre recombinase/loxP system to create a mouse line in which PKA activity can be inhibited in any cell-type that expresses Cre recombinase. The mouse line carries a mutant Prkar1a allele encoding a glycine to aspartate substitution at position 324 in the carboxy-terminal cAMP-binding...

Descripción completa

Detalles Bibliográficos
Autores principales:	Willis, Brandon S., Niswender, Colleen M., Su, Thomas, Amieux, Paul S., McKnight, G. Stanley
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075275/ https://www.ncbi.nlm.nih.gov/pubmed/21533282 http://dx.doi.org/10.1371/journal.pone.0018772

Ejemplares similares

Hypothalamic PKA regulates leptin sensitivity and adiposity
por: Yang, Linghai, et al.
Publicado: (2015)

Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cβ2
por: Funderud, Ane, et al.
Publicado: (2006)

RiboTag Analysis of Actively Translated mRNAs in Sertoli and Leydig Cells In Vivo
por: Sanz, Elisenda, et al.
Publicado: (2013)

Cell-type specific asynchronous modulation of PKA by dopamine in learning
por: Lee, Suk Joon, et al.
Publicado: (2020)

PKA-RIIβ autophosphorylation modulates PKA activity and seizure phenotypes in mice
por: Zhang, Jingliang, et al.
Publicado: (2021)

Mutations in AKAP5 Disrupt Dendritic Signaling Complexes and Lead to Electrophysiological and Behavioral Phenotypes in Mice
por: Weisenhaus, Michael, et al.
Publicado: (2010)

Isoform-specific targeting of PKA to multivesicular bodies
por: Day, Michele E., et al.
Publicado: (2011)

Induction of dominant mutations that cause skeletal malformations in mice
por: Selby, Paul B.
Publicado: (1978)

Human RELA dominant-negative mutations underlie type I interferonopathy with autoinflammation and autoimmunity
por: Moriya, Kunihiko, et al.
Publicado: (2023)

Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease
por: Sun, Yongzhan, et al.
Publicado: (2019)

Dominant-negative heterozygous mutations in AIRE confer diverse autoimmune phenotypes
por: Oftedal, Bergithe E., et al.
Publicado: (2023)

Molecular Basis for Ser/Thr Specificity in PKA Signaling
por: Knape, Matthias J., et al.
Publicado: (2020)

The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA
por: Vetter, Maike M, et al.
Publicado: (2011)

High-throughput identification of dominant negative polypeptides in yeast
por: Dorrity, Michael W., et al.
Publicado: (2019)

A dominant negative approach to reduce xylan in plants
por: Brandon, Andrew G., et al.
Publicado: (2019)

Impact of kinase activating and inactivating patient mutations on binary PKA interactions
por: Röck, Ruth, et al.
Publicado: (2015)

Multiple components of PKA and TGF-β pathways are mutated in pseudomyxoma peritonei
por: Saarinen, Lilli, et al.
Publicado: (2017)

Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
por: Quintana, Albert, et al.
Publicado: (2012)

Concept map of dispositional humility among professionals in an interdisciplinary healthcare environment: qualitative synthesis
por: Sasagawa, Masa, et al.
Publicado: (2019)

Dispositional Humility Of Clinicians In An Interprofessional Primary Care Environment: A Mixed Methods Study
por: Sasagawa, Masa, et al.
Publicado: (2019)

Limited importance of the dominant-negative effect of TP53 missense mutations
por: Stoczynska-Fidelus, Ewelina, et al.
Publicado: (2011)

Huntingtin CAG-expansion mutation results in a dominant negative effect
por: Laundos, Tiago L., et al.
Publicado: (2023)

Isoform-Specific Dominant-Negative Effects Associated with hERG1 G628S Mutation in Long QT Syndrome
por: Stump, Matthew R., et al.
Publicado: (2012)

Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
por: Gidon, Alexandre, et al.
Publicado: (2014)

Corrigendum: Impact of kinase activating and inactivating patient mutations on binary PKA interactions
por: Röck, Ruth, et al.
Publicado: (2015)

Dominant negative retinoic acid receptor initiates tumor formation in mice
por: Kupumbati, Tara S, et al.
Publicado: (2006)

Functional Analysis of a Dominant Negative Mutation of Interferon Regulatory Factor 5
por: Yang, Long, et al.
Publicado: (2009)

PKA steers growth cones
por: LeBrasseur, Nicole
Publicado: (2007)

Centrosomes are PKA's sensitive spot
por: Short, Ben
Publicado: (2012)

Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype–phenotype correlations, codon bias and dominant-negative effects
por: Hannan, Fadil M., et al.
Publicado: (2015)

PKC and PKA Regulate AChR Dynamics at the Neuromuscular Junction of Living Mice
por: Martinez-Pena y Valenzuela, Isabel, et al.
Publicado: (2013)

MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction
por: Harada, Akihiro, et al.
Publicado: (2002)

Participation of Myosin Va and Pka Type I in the Regeneration of Neuromuscular Junctions
por: Röder, Ira Verena, et al.
Publicado: (2012)

Mapping functional regions of essential bacterial proteins with dominant-negative protein fragments
por: Savinov, Andrew, et al.
Publicado: (2022)

Inhibition of Elastase-Pulmonary Emphysema in Dominant-Negative MafB Transgenic Mice
por: Aida, Yasuko, et al.
Publicado: (2014)

Disruption of T Cell Homeostasis in Mice Expressing a T Cell–Specific Dominant Negative Transforming Growth Factor β II Receptor
por: Lucas, Philip J., et al.
Publicado: (2000)

Dominant negative Bmp5 mutation reveals key role of BMPs in skeletal response to mechanical stimulation
por: Ho, Andrew M, et al.
Publicado: (2008)

Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in mice
por: Kis, Adrienn, et al.
Publicado: (2009)

Dominant negative Gfi1b mutations cause moderate thrombocytopenia and an impaired stress thrombopoiesis associated with mild erythropoietic abnormalities in mice
por: Beauchemin, Hugues, et al.
Publicado: (2019)

ETV6-related thrombocytopenia: dominant negative effect of mutations as common pathogenic mechanism
por: Faleschini, Michela, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_7cniv6dcr1i4m9l2o234pr4f26