Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b(+)Ly6G(+) immature myeloid cells

Histidine decarboxylase (HDC), the unique enzyme responsible for histamine generation, is highly expressed in myeloid cells but its function is poorly understood. Here, we show that Hdc knockout mice exhibit a markedly increased rate of colon and skin carcinogenesis. Using Hdc-EGFP BAC transgenic mi...

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Detalles Bibliográficos
Autores principales: Yang, Xiang Dong, Ai, Walden, Asfaha, Samuel, Bhagat, Govind, Friedman, Richard A., Jin, Guangchun, Park, Heuijoon, Shykind, Benjamin, Diacovo, Thomas G, Falus, Andras, Wang, Timothy C
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075560/
https://www.ncbi.nlm.nih.gov/pubmed/21170045
http://dx.doi.org/10.1038/nm.2278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075560/
https://www.ncbi.nlm.nih.gov/pubmed/21170045
http://dx.doi.org/10.1038/nm.2278

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