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The Hidden Energetics of Ligand-Binding and Activation in a Glutamate Receptor
Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the majority of excitatory synaptic transmission in the central nervous system. The free energy of neurotransmitter-binding to the ligand-binding domains (LBDs) of iGluRs is converted into useful work to drive recepto...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075596/ https://www.ncbi.nlm.nih.gov/pubmed/21317895 http://dx.doi.org/10.1038/nsmb.2010 |