Crystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide Class

[Image: see text] ABL2 (also known as ARG (ABL related gene)) is closely related to the well-studied Abelson kinase cABL. ABL2 is involved in human neoplastic diseases and is deregulated in solid tumors. Oncogenic gene translocations occur in acute leukemia. So far no structural information for ABL2...

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Detalles Bibliográficos
Autores principales: Salah, Eidarus, Ugochukwu, Emilie, Barr, Alastair J., von Delft, Frank, Knapp, Stefan, Elkins, Jonathan M.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075623/
https://www.ncbi.nlm.nih.gov/pubmed/21417343
http://dx.doi.org/10.1021/jm101506n

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075623/
https://www.ncbi.nlm.nih.gov/pubmed/21417343
http://dx.doi.org/10.1021/jm101506n

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