Deubiquitinase HAUSP Stabilizes REST and Promotes Maintenance of Neural Progenitor Cells

The repressor element 1-silencing transcription factor (REST) functions as a master regulator to maintain neural stem/progenitor cells (NPCs). REST undergoes proteasomal degradation through β-TrCP-mediated ubiquitination during neuronal differentiation. However, reciprocal mechanisms that stabilize...

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Detalles Bibliográficos
Autores principales: Huang, Zhi, Wu, Qiulian, Guryanova, Olga A., Cheng, Lin, Shou, Weinian, Rich, Jeremy N., Bao, Shideng
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076066/
https://www.ncbi.nlm.nih.gov/pubmed/21258371
http://dx.doi.org/10.1038/ncb2153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076066/
https://www.ncbi.nlm.nih.gov/pubmed/21258371
http://dx.doi.org/10.1038/ncb2153

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