Deregulation of MYCN, LIN28B and LET7 in a Molecular Subtype of Aggressive High-Grade Serous Ovarian Cancers

Molecular subtypes of serous ovarian cancer have been recently described. Using data from independent datasets including over 900 primary tumour samples, we show that deregulation of the Let-7 pathway is specifically associated with the C5 molecular subtype of serous ovarian cancer. DNA copy number...

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Detalles Bibliográficos
Autores principales: Helland, Åslaug, Anglesio, Michael S., George, Joshy, Cowin, Prue A., Johnstone, Cameron N., House, Colin M., Sheppard, Karen E., Etemadmoghadam, Dariush, Melnyk, Nataliya, Rustgi, Anil K., Phillips, Wayne A., Johnsen, Hilde, Holm, Ruth, Kristensen, Gunnar B., Birrer, Michael J., Pearson, Richard B., Børresen-Dale, Anne-Lise, Huntsman, David G., deFazio, Anna, Creighton, Chad J., Smyth, Gordon K., Bowtell, David D. L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076323/
https://www.ncbi.nlm.nih.gov/pubmed/21533284
http://dx.doi.org/10.1371/journal.pone.0018064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076323/
https://www.ncbi.nlm.nih.gov/pubmed/21533284
http://dx.doi.org/10.1371/journal.pone.0018064

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